Chris Smalling should replace suspended Gianluca Mancini, with Lorenzo Pellegrini, Henrikh Mkhitaryan and Edin Dzeko in Roma’s Europa League semi-final with Manchester United.
The first leg kicks off at Old Trafford on Thursday at 20.00 UK time (19.00 GMT).
Paulo Fonseca is glad to see the injury crisis finally beginning to calm down, although Pedro Rodriguez, Riccardo Calafiori, Nicolò Zaniolo and Stephan El Shaarawy are still out of action.
Above all, Mancini is suspended, but the good news is that Smalling returns and is ready to start against his former club.
Jordan Veretout is also back in midfield, with Amadou Diawara the favourite rather than Gonzalo Villar.
Dzeko should lead the attack with support from Pellegrini and Mkhitaryan.
Manchester United have almost a full squad to choose from, missing only Anthony Martial and Phil Jones, as even Marcus Rashford is available after his ankle issue.
Paul Pogba and Edinson Cavani were both rested for the 0-0 draw with Leeds United at the weekend.
Harry Maguire, Luke Shaw and Scott McTominay return after they were suspended for the second leg of the quarter-final with Granada.
There are several former Serie A players to watch out for, including Pogba, Cavani and Bruno Fernandes.
Manchester United (4-2-3-1): De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Rashford, Fernandes, Pogba; Cavani
Man Utd bench: Grant, Henderson, Fish, Williams, van de Beek, Mata, Elanga, James, Shoretire, Greenwood, Diallo
Roma (3-4-2-1): Pau Lopez; Smalling, Cristante, Ibanez; Karsdorp, Diawara, Veretout, Spinazzola; Pellegrini, Mkhitaryan; Dzeko
Roma bench: Mirante, Fuzato, Kumbulla, Santon, Peres, Villar, Ciervo, Darboe, Perez, Mayoral
Ref: Del Cerro Grande (ESP)